ABP-7 (10mg)

ABP-7 Peptide

ABP-7 (Actin Binding Peptide-7) is a synthetic heptapeptide composed of seven amino acids with the sequence Acetyl-LKKTETQ. It represents the N-terminal 17–23 amino acid fragment of Thymosin Beta 4 (TB-500) and is often referred to as a TB-500 fragment.

Researchers consider the LKKTETQ sequence the primary actin-binding domain of thymosin beta 4. Due to this relationship, ABP-7 is believed to exhibit similar actin-binding properties and biological activities.

ABP-7 may influence cellular processes by regulating actin dynamics. Actin is a key component of the cellular cytoskeleton and plays an essential role in cell structure, movement, shape changes, intracellular transport, and signal transduction. By interacting with actin, ABP-7 may affect cellular migration and tissue remodeling, making it a subject of interest in regenerative and cellular research.

Chemical Information

• Molecular Formula: C38H81N9O20
• Molecular Weight: 889.5 g/mol
• Also Known As: TB-500 Fragment, Ac-LKKTETQ

Research Applications

ABP-7 and Wound Healing

Research suggests that ABP-7 may support wound repair by promoting keratinocyte migration, collagen deposition, and tissue regeneration. Studies involving aged and diabetic animal models have reported wound-healing activity comparable to that of the parent molecule, thymosin beta 4. You can buy ABP-7 10mg peptide from our store.

Potential mechanisms include:

• Enhanced epidermal cell migration
• Increased collagen deposition
• Support for tissue remodeling
• Modulation of intracellular calcium signaling
• Influence on actin cytoskeleton dynamics

These activities have made ABP-7 an area of interest in regenerative medicine and tissue repair research.

ABP-7 and Fibrosis Research

ABP-7 has been investigated for its potential effects on hepatic stellate cells (HSCs), which play a central role in liver fibrosis.

Research indicates that ABP-7 may:

• Reduce PDGF-BB-induced cellular activation
• Decrease expression of fibrosis-related markers, including α-SMA and collagen type I
• Inhibit Akt and PRAS40 signaling pathways
• Limit the proliferation and migration of activated hepatic stellate cells

These findings suggest a potential role for ABP-7 in fibrosis-related research and cellular signaling studies.

ABP-7 and Angiogenesis

ABP-7 has also been studied for its possible involvement in angiogenesis, the formation of new blood vessels.

Research suggests that ABP-7 may support:

• Endothelial cell migration
• Tube formation in vitro
• Early vessel sprouting processes
• Cytoskeletal remodeling required for vascular development

Its actin-binding properties may contribute to cellular structural changes that facilitate new blood vessel formation, although further investigation is needed to fully understand these mechanisms.